The Yorozuya get a new neighbor, a frightening looking Amanto named Hedoro, and they assume he's up to something...
- Sakata Gintoki
- Shimura Shinpachi
- Otose (flashback)
- Sadaharu (cameo)
- Hedoro (debut)
- Catherine (cameo)
- Hiraga Gengai (Kagura's daydream)
- When Gin is walking with Kagura dressed as a baby outside Hedoro's shop, they parody the manga Kozure O-Kami. Later in Episode 218.
- When the gang is sneezing, they say many different names of known characters. Among them we can spot; Setouchi Jackson (a character from Comartie High School series), Edith Hanson (an American personality in Japanese TV) and Michael & Janet Jackson (the famous singers)
- When Gin is trying to prove that Hedoro would eat a innocent kitty, he makes a slight reference to Megaman 8's Opening "Electrical Communication"